TN-16

• Description:

  TN-16 is a potent inhibitor of microtubule polymerization with IC50 of 0.4-1.7 µM[1].

• Product Name Alternative:

  Rovamycin

• UNSPSC:

  12352005

• Hazard Statement:

  H317, H400

• Target:

  Microtubule/Tubulin

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage; Cytoskeleton

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/tn-16.html

• Purity:

  99.78

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  O=C(NC(C/1=O)CC2=CC=CC=C2)C1=C(C)/NC3=CC=CC=C3

• Molecular Formula:

  C19H18N2O2

• Molecular Weight:

  306.36

• Precautions:

  H317, H400

• References & Citations:

  [1]Arai T. Inhibition of microtubule assembly in vitro by TN-16, a synthetic antitumor drug. FEBS Lett. 1983 May 8;155 (2) :273-6.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [33016-12-5]