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Hydrocinchonine (Standard)

CAT: 0804-HY-W035709RSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-W035709RSize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Hydrocinchonine (Dihydrocinchonine) (Standard) is the analytical standard of Hydrocinchonine. This product is used for research and analytical purposes.Hydrocinchonine is a multidrug resistance (MDR) -reversal agent. Hydrocinchonine directly inhibits the function and expression of P-gp, which is the mechanism by which it reverses MDR. Hydrocinchonine exerts synergistic apoptotic effect with Paclitaxel (HY-B0015) in MES-SA/DX5 cells. Hydrocinchonine can be used for the study of gynecological malignant tumors (such as uterine sarcoma) with drug resistance caused by excessive expression of P-gp[1].
CAS Number
485-65-4
Product Name Alternative
Dihydrocinchonine (Standard)
UNSPSC
12352005
Target
Apoptosis; P-glycoprotein; Reference Standards
Related Pathways
Apoptosis; Membrane Transporter/Ion Channel; Others
Field of Research
Cancer
Smiles
O[C@@H](C1=CC=NC2=C1C=CC=C2)[C@]3([H])[N@@](CC4)C[C@H](CC)[C@]4([H])C3
Molecular Formula
C19H24N2O
Molecular Weight
296.41
References & Citations
[1]Sang-Yun Lee, et al. Hydrocinchonine, cinchonine, and quinidine potentiate paclitaxel-induced cytotoxicity and apoptosis via multidrug resistance reversal in MES-SA/DX5 uterine sarcoma cells. Environ Toxicol. 2011 Aug;26 (4) :424-31.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Clinical Information
No Development Reported

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