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Hydrocinchonine

CAT: 0804-HY-W035709-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W035709-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Hydrocinchonine (Dihydrocinchonine) is a multidrug resistance (MDR) -reversal agent. Hydrocinchonine directly inhibits the function and expression of P-gp, which is the mechanism by which it reverses MDR. Hydrocinchonine exerts synergistic apoptotic effect with Paclitaxel in MES-SA/DX5 cells. Hydrocinchonine can be used for the study of gynecological malignant tumors (such as uterine sarcoma) with drug resistance caused by excessive expression of P-gp[1].
CAS Number
485-65-4
Product Name Alternative
Dihydrocinchonine
UNSPSC
12352005
Hazard Statement
H302
Target
Apoptosis; P-glycoprotein
Type
Reference compound
Related Pathways
Apoptosis; Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hydrocinchonine.html
Purity
98.33
Solubility
10 mM in DMSO
Smiles
O[C@@H](C1=CC=NC2=C1C=CC=C2)[C@]3([H])[N@@](CC4)C[C@H](CC)[C@]4([H])C3
Molecular Formula
C19H24N2O
Molecular Weight
296.41
Precautions
H302
References & Citations
[1]Sang-Yun Lee, et al. Hydrocinchonine, cinchonine, and quinidine potentiate paclitaxel-induced cytotoxicity and apoptosis via multidrug resistance reversal in MES-SA/DX5 uterine sarcoma cells. Environ Toxicol. 2011 Aug;26 (4) :424-31.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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