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5-Iodouracil

CAT: 0804-HY-W001983-01Size: 25 gDry Ice: NoHazardous: No
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CAT#:0804-HY-W001983-01Size:25 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
5-Iodouracil (Compound 4b) is an irreversible dihydropyrimidine dehydrogenase (DPD) inhibitor (IC50=0.22 μM) . 5-Iodouracil is promising for research of DPD-overexpressing solid tumors like non-small cell lung cancer (NSCLC) [1].
CAS Number
696-07-1
UNSPSC
12352005
Hazard Statement
H302+H312+H332, H315, H319, H335
Target
Dihydropyrimidine Dehydrogenase (DPD)
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Purity
99.95
Smiles
O=C1NC=C(I)C(=O)N1
Molecular Formula
C4H3IN2O2
Molecular Weight
237.98
Precautions
H302+H312+H332, H315, H319, H335
References & Citations
[1]Hattori K, et al. Design and synthesis of the tumor-activated prodrug of dihydropyrimidine dehydrogenase (DPD) inhibitor, RO0094889 for combination therapy with capecitabine. Bioorg Med Chem Lett. 2003 Mar 10;13 (5) :867-72.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound2
Clinical Information
No Development Reported

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