Products for Research Use Only
RegisterLogin

AG01

CAT: 0804-HY-P991664Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-P991664Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
AG01 is a monoclonal antibody against progranulin (GP88) . AG01 inhibits triple-negative breast cancer (TNBC) cell proliferation and migration, reduces the expression of phosphorylated protein kinases p-Src, p-AKT, and p-ERK, and reduces the expression of oncogenic proteins such as Axl, c-MET, HIF-1α, and VEGF. AG01 inhibits tumor growth and Ki67 expression in a TNBC xenograft mouse model. AG01 can be used in the research of TNBC and other cancers[1].
UNSPSC
12352100
Target
Akt; c-Met/HGFR; ERK; HIF/HIF Prolyl-Hydroxylase; MMP; Src; TAM Receptor; VEGFR
Related Pathways
MAPK/ERK Pathway; Metabolic Enzyme/Protease; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
References & Citations
[1]Guha R, et al. Anti-progranulin/GP88 antibody AG01 inhibits triple negative breast cancer cell proliferation and migration. Breast Cancer Res Treat. 2021 Apr;186 (3) :637-653.
Shipping Conditions
Room temperature
Scientific Category
Inhibitory Antibodies
Clinical Information
No Development Reported
Isoform
Axl; ERK1; ERK2; HIF-1α; MMP-2

Related Products

CatalogName
HY-P10861RI-AG03
HY-P10861A-01RI-AG03 (acetate)

Alternative Products

CatalogName
T9901A-1846-01AG01
GTR18775391-01AG01 Antibody

Popular Products