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AG01

CAT: 0931-T9901A-1846-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T9901A-1846-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Target
Src, TAM Receptor, c-Met/HGFR, MMP, ERK, HIF/HIF Prolyl-Hydroxylase, Akt, VEGFR
Related Pathways
PI3K/Akt/mTOR signaling, MAPK, Angiogenesis, Proteases/Proteasome, Metabolism, Chromatin/Epigenetic, Cytoskeletal Signaling, Tyrosine Kinase/Adaptors
Bioactivity
AG01 is a monoclonal antibody targeting the anti-granular protein precursor (GP88) . It inhibits the proliferation and migration of triple-negative breast cancer (TNBC) cells, reducing the expression of phosphorylated protein kinases such as p-Src, p-AKT, and p-ERK, as well as oncogenic proteins like Axl, c-MET, HIF-1α, and VEGF. In TNBC xenograft mouse models, AG01 suppresses tumor growth and the expression of Ki67 in vivo. AG01 is useful for research involving cancers like TNBC.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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