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AMG-966

CAT: 0804-HY-P991440-01Size: 1 mgDry Ice: YesHazardous: No
CAT#:0804-HY-P991440-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AMG-966 is a human bispecific antibody (bsAb) targeting TNFSF15/TL1A & TNFα. AMG 966 restores the ability of the aglycosylated Fc domain to bind to FcγRIa and FcγRIIa, leading to the formation of antidrug antibodies (ADA) . AMG-966 can be used in Crohn's disease and Ulcerative colitis research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) [1].
UNSPSC
12352203
Target
TNF Receptor
Related Pathways
Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Purity
96.19
Smiles
[AMG-966]
Molecular Weight
(145.25 kDa)
References & Citations
[1]Kroenke MA, et al. Immune Complex Formation Is Associated With Loss of Tolerance and an Antibody Response to Both Drug and Target. Front Immunol. 2021 Dec 14;12:782788.
Shipping Conditions
Dry Ice
Storage Conditions
-80°C
Scientific Category
Inhibitory Antibodies
Clinical Information
No Development Reported

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T9901A-1095-01AMG-966
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524203AM-966
DHB54006Research Grade Anti-Human TNFSF15/TL1A & TNFa/TNF-alpha Antibody (AMG 966)
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