(S) - (-) -HA 966

CAT: 0804-HY-100822ASize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-100822ASize:1 Each
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Description
(S) - (-) -HA 966 ((-) -HA 966), a γ-Hydroxybutyrate-like agent, is weakly active as an NMDA-receptor antagonist. (S) - (-) -HA 966 possesses muscle relaxant action and prevents enhanced mesocorticolimbic dopamine metabolism and behavioral correlates of restraint stress, conditioned fear[1][2].
CAS Number
[111821-58-0]
Product Name Alternative
(-) -HA 966
UNSPSC
12352005
Hazard Statement
H315-H319-H335
Target
IGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/s-minus-ha-966.html
Purity
98.0
Solubility
10 mM in DMSO
Smiles
O=C1N(O)CC[C@@H]1N
Molecular Formula
C4H8N2O2
Molecular Weight
116.12
Precautions
P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501
References & Citations
[1]B A Morrow, et al. (S) - (-) -HA-966, a gamma-hydroxybutyrate-like agent, prevents enhanced mesocorticolimbic dopamine metabolism and behavioral correlates of restraint stress, conditioned fear and cocaine sensitization. J Pharmacol Exp Ther. 1997 Nov;283 (2) :712-21.|[2]L Singh, et al. Enantiomers of HA-966 (3-amino-1-hydroxypyrrolid-2-one) exhibit distinct central nervous system effects: (+) -HA-966 is a selective glycine/N-methyl-D-aspartate receptor antagonist, but (-) -HA-966 is a potent gamma-butyrolactone-like sedative. Proc Natl Acad Sci U S A. 1990 Jan;87 (1) :347-51.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NMDA Receptor

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