MAIT-203 (acetate)

• Description:

  MAIT-203 acetate is a cyclopentyalanin-derived peptidomimetic, potently inhibits the interaction of adenomatous polyposis coli (APC) and Asef (RhoGEF4), but not APC-Sam68 or APC-striatin interactions. MAIT-203 acetate binds APC-ARM with a Ki value of 0.015 μM and aKd value of 0.036 μM. MAIT-203 acetate significantly represses the migration and invasion of colorectal cancer cells[1].

• UNSPSC:

  12352209

• Target:

  Drug Derivative

• Related Pathways:

  Others

• Field of Research:

  Cancer

• Purity:

  99.12

• Smiles:

  [Cbz-Ala-Gly-Glu-Ala-{S-3cyclopentylalamine}-Tyr-Glu-Gly-Gly-Gly-Gly-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-NH2 (acetate salt) ]

• Molecular Formula:

  C106H177N43O29.xC2H4O2

• Molecular Weight:

  2517.85 (free base)

• References & Citations:

  [1]Haiming Jiang, et al. Peptidomimetic Inhibitors of APC-Asef Interaction Block Colorectal Cancer Migration. Nat Chem Biol. 2017 Sep;13 (9) :994-1001.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported