Ac-FR-AFC (TFA)

• Description :

  Ac-FR-AFC TFA is a Cathepsin L fluorogenic substrate (Ex=400 nm, Em=505 nm) . Cathepsin L activity in cells lysates is determined by measuring cleavage of Ac-FR-AFC TFA and its cleavage occurs at the FR-AFC amide bond. Ac-FR-AFC TFA can be used for activity assays and mechanistic studies on cathepsin L[1].

• UNSPSC :

  12352209

• Target :

  Cathepsin; Fluorescent Dye

• Related Pathways :

  Metabolic Enzyme/Protease; Others

• Field of Research :

  Others

• Smiles :

  OC(C(F)(F)F)=O.NC(NCCC[C@H](NC([C@@H](NC(C)=O)CC1=CC=CC=C1)=O)C(NC2=CC=C(C(C(F)(F)F)=CC(O3)=O)C3=C2)=O)=N

• Molecular Formula :

  C29H30F6N6O7

• Molecular Weight :

  688.57

• References & Citations :

  [1]Zhang X, et al. Trifluoperazine, a novel autophagy inhibitor, increases radiosensitivity in glioblastoma by impairing homologous recombination. J Exp Clin Cancer Res. 2017 Sep 5;36 (1) :118.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Peptides

• Clinical Information :

  No Development Reported

• Isoform :

  Cathepsin L