Oncocin

CAT: 0931-TP3888-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-TP3888-01Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

1235497-90-1

Target

Antibacterial

Related Pathways

Microbiology/Virology

Bioactivity

Oncocin is an antibacterial peptide classified under proline-rich antimicrobial peptides (PrAMPs) . It is effective against Gram-negative bacteria, exhibiting a minimum inhibitory concentration (MIC) range of 0.125-8 μg/mL for 34 clinical isolates and strains of Enterobacteriaceae and non-fermentative bacteria. Oncocin interacts with the substrate-binding domain of the chaperone protein DnaK, with a dissociation constant in the micromolar range. This interaction results in protein misfolding and aggregation, ultimately causing bacterial cell death.

Smiles

C(=O)([C@H]1N(C([C@@H](NC(=O)[C@H]2N(C([C@@H](NC(=O)[C@H]3N(C([C@@H](NC([C@@H](NC(=O)[C@H]4N(C(=O)[C@H]5N(C([C@@H](NC([C@@H](NC([C@H](C(C)C)N)=O)CC(O)=O)=O)CCCCN)=O)CCC5)CCC4)CC6=CC=C(O)C=C6)=O)CC(C)C)=O)CCC3)CCCNC(=N)N)=O)CCC2)CCCNC(=N)N)=O)CCC1)N7[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC8=CC=C(O)C=C8)C(N[C@H](C(N[C@@H](CCCNC(=N)N)C(N)=O)=O)CC(N)=O)=O)=O)[C@H](CC)C)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCC7

Molecular Formula

C109H177N37O24

Molecular Weight

2389.8

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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