TE-8105

• Description :

  TE-8105 is a GLP-1 receptor agonist that has demonstrated prolonged and potent efficacy in models of diabetes, obesity, and non-alcoholic steatohepatitis (NASH) [1].

• UNSPSC :

  12352209

• Target :

  GLP Receptor

• Related Pathways :

  GPCR/G Protein

• Field of Research :

  Metabolic Disease

• Smiles :

  [H]N[C@@H](CC1=CN=CN1)C(NC(C)(C)C(N[C@H](C(NCC(N[C@H](C(N[C@@H](CC2=CC=CC=C2)C(N[C@H](C(N[C@H](C(N[C@@H](CC(O)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC3=CC=C(C=C3)O)C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@@H](C)C(N[C@@H](C)C(N[C@H](C(N[C@H](C(N[C@@H](CC4=CC=CC=C4)C(N[C@@H]([C@H](CC)C)C(N[C@@H](C)C(N[C@@H](CC5=CNC6=C5C=CC=C6)C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(NCC(O)=O)=O)CCCNC(N)=N)=O)=O)CCCNC(N)=N)=O)C(C)C)=O)CC(C)C)=O)=O)=O)=O)=O)CCC(O)=O)=O)CCCCNC(CC[C@H](NC(CN7N=NC(CCC(NCCOCCOCCOCCOCCC(N[C@@H](C(NCCOCCOCCOCCOCCC(N[C@@H](C(O)=O)CCCCNC(CC[C@@H](NC(CCCCCCCCCCCCCCCCC(O)=O)=O)C(O)=O)=O)=O)=O)CCCCNC(CC[C@H](NC(CCCCCCCCCCCCCCC)=O)C(O)=O)=O)=O)=O)=C7)=O)C(O)=O)=O)=O)=O)=O)CCC(N)=O)=O)=O)CCC(O)=O)=O)CC(C)C)=O)=O)CO)=O)CO)=O)C(C)C)=O)=O)CO)=O)[C@@H](C)O)=O)=O)[C@@H](C)O)=O)=O)CCC(O)=O)=O)=O

• Molecular Formula :

  C242H386N54O75

• Molecular Weight :

  5251.97

• References & Citations :

  [1]Wong MT, et al. 2FA-Platform Generates Dual Fatty Acid-Conjugated GLP-1 Receptor Agonist TE-8105 with Enhanced Diabetes, Obesity, and NASH Efficacy Compared to Semaglutide. J Med Chem. 2025 Mar 27;68 (6) :6178-6192.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Peptides

• Clinical Information :

  No Development Reported