M1-20

• Target :

  CDK

• Related Pathways :

  Cell Cycle/Checkpoint

• Bioactivity :

  M1-20 is a CDK1 inhibitor. It promotes the ubiquitination of CDK1 through the CUL4-DDB1-DCAF1 complex, leading to its degradation via the proteasome pathway. M1-20 inhibits the formation of the CDK1/CCNB1 complex and exhibits significant anticancer activity against spontaneous breast cancer in the FVB/N MMTV-PyVT mouse model.

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C