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Citrocin

CAT: 0804-HY-P10980Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-P10980Size:1 Each
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Description
Citrocin is a potent bacterial RNA polymerase (RNAP) inhibitor. Citrocin shows significant inhibitory activity against Escherichia coli RNAP with an MIC range of 16-125 μM. Citrocin specifically binds to and inhibits RNA polymerase to block bacterial transcription and enters cells mainly through inner membrane protein SbmA. Citrocin is promising for research of Gram-negative bacterial infections, such as enterohemorrhagic E. coli[1].
UNSPSC
12352209
Target
Bacterial
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Smiles
O=C(NCC(N[C@@H](C(C)C)C(NCC(N[C@@H](CCCCN)C(N[C@@H]([C@@H](C)CC)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC1)C(N[C@@H](CC2=CC=C(C=C2)O)C(N[C@@H](CC3=CC=CC=C3)C(N[C@@H]([C@@H](C)CC)C(NCC(NCC(NCC(N[C@@H](C(C)C)C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC4=CC=C(C=C4)O)C(NCC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CNC1=O
Molecular Formula
C88H133N23O23
Molecular Weight
1881.14
References & Citations
[1]Cheung-Lee WL, et al. Discovery and structure of the antimicrobial lasso peptide citrocin. J Biol Chem. 2019 Apr 26;294 (17) :6822-6830.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

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