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Citrinin (Standard)

CAT: 0804-HY-N6746RSize: 1 EachDry Ice: NoHazardous: No
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Description
Citrinin (Standard) is the analytical standard of Citrinin. This product is intended for research and analytical applications. Citrinin (NSC 186) is a mycotoxin that causes food contamination and has different toxic effects. Citrinin is an effective oral anticancer agent. Citrinin has various regulatory effects on mouse immune system, including regulating the number of immune cells, inducing apoptosis and autophagy of immune cells, altering toll-like receptor expression and cytokine production. Citrinin can induce oxidative stress and lead to early apoptosis of oocytes. Low doses of Citrinin have neuroprotective effects against glutamate-induced excitotoxicity in rat cortical neurons. In addition, Citrinin also has antibacterial activity[1][2][3][4][5].
CAS Number
518-75-2
Product Name Alternative
NSC 186 (Standard)
UNSPSC
12352005
Target
Apoptosis; Bacterial; Endogenous Metabolite; Fungal; Reference Standards
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis; Metabolic Enzyme/Protease; Others
Field of Research
Cancer; Infection; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/citrinin-standard.html
Smiles
O=C1C(C)=C2[C@H]([C@@H](OC=C2C(O)=C1C(O)=O)C)C
Molecular Formula
C13H14O5
Molecular Weight
250.25
References & Citations
[1]de Oliveira Filho JWG, et al, A comprehensive review on biological properties of citrinin. Food Chem Toxicol. 2017 Dec;110:130-141.|[2]Čulig B, et al. PRESENCE OF CITRININ IN GRAINS AND ITS POSSIBLE HEALTH EFFECTS. Afr J Tradit Complement Altern Med. 2017 Mar 1;14 (3) :22-30|[3]de Oliveira Filho JWG, et al, A comprehensive review on biological properties of citrinin. Food Chem Toxicol. 2017 Dec;110:130-141.|[4]Islam MR, et al. Immune modulatory effects of the foodborne contaminant citrinin in mice. Food Chem Toxicol. 2012 Oct;50 (10) :3537-47.|[5]de Oliveira Filho JWG, et al. Citrinin against breast cancer: A cytogenotoxicological study. Phytother Res. 2021 Jan;35 (1) :504-516.|[6]Nakajima Y, et al. Low doses of the mycotoxin citrinin protect cortical neurons against glutamate-induced excitotoxicity. J Toxicol Sci. 2016 Apr;41 (2) :311-9.|[7]Wu Y, et al. Citrinin exposure affects oocyte maturation and embryo development by inducing oxidative stress-mediated apoptosis. Oncotarget. 2017 May 23;8 (21) :34525-34533.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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