Citrinin

• Description :

  Citrinin (NSC 186) is a mycotoxin that causes food contamination and has different toxic effects. Citrinin is an effective oral anticancer agent. Citrinin has various regulatory effects on mouse immune system, including regulating the number of immune cells, inducing apoptosis and autophagy of immune cells, altering toll-like receptor expression and cytokine production. Citrinin can induce oxidative stress and lead to early apoptosis of oocytes. Low doses of Citrinin have neuroprotective effects against glutamate-induced excitotoxicity in rat cortical neurons. In addition, Citrinin also has antibacterial activity[1][2][3][4][5].

• Product Name Alternative :

  NSC 186

• UNSPSC :

  12352005

• Hazard Statement :

  H301, H311, H331, H351

• Target :

  Apoptosis; Bacterial; Endogenous Metabolite; Fungal

• Type :

  Natural Products

• Related Pathways :

  Anti-infection; Apoptosis; Metabolic Enzyme/Protease

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Cancer; Infection; Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/citrinin.html

• Purity :

  99.94

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  O=C1C(C)=C2[C@H]([C@@H](OC=C2C(O)=C1C(O)=O)C)C

• Molecular Formula :

  C13H14O5

• Molecular Weight :

  250.25

• Precautions :

  H301, H311, H331, H351

• References & Citations :

  [1]de Oliveira Filho JWG, et al, A comprehensive review on biological properties of citrinin. Food Chem Toxicol. 2017 Dec;110:130-141.|[2]Islam MR, et al. Immune modulatory effects of the foodborne contaminant citrinin in mice. Food Chem Toxicol. 2012 Oct;50 (10) :3537-47.|[3]de Oliveira Filho JWG, et al. Citrinin against breast cancer: A cytogenotoxicological study. Phytother Res. 2021 Jan;35 (1) :504-516.|[4]Nakajima Y, et al. Low doses of the mycotoxin citrinin protect cortical neurons against glutamate-induced excitotoxicity. J Toxicol Sci. 2016 Apr;41 (2) :311-9.|[5]Wu Y, et al. Citrinin exposure affects oocyte maturation and embryo development by inducing oxidative stress-mediated apoptosis. Oncotarget. 2017 May 23;8 (21) :34525-34533.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, stored under nitrogen)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• Isoform :

  Microbial Metabolite

• CAS Number :

  [518-75-2]