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Citrinin

CAT: 0804-HY-N6746-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N6746-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Citrinin (NSC 186) is a mycotoxin that causes food contamination and has different toxic effects. Citrinin is an effective oral anticancer agent. Citrinin has various regulatory effects on mouse immune system, including regulating the number of immune cells, inducing apoptosis and autophagy of immune cells, altering toll-like receptor expression and cytokine production. Citrinin can induce oxidative stress and lead to early apoptosis of oocytes. Low doses of Citrinin have neuroprotective effects against glutamate-induced excitotoxicity in rat cortical neurons. In addition, Citrinin also has antibacterial activity[1][2][3][4][5].
CAS Number
518-75-2
Product Name Alternative
NSC 186
UNSPSC
12352005
Hazard Statement
H301, H311, H331, H351
Target
Apoptosis; Bacterial; Endogenous Metabolite; Fungal
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/citrinin.html
Purity
99.94
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C1C(C)=C2[C@H]([C@@H](OC=C2C(O)=C1C(O)=O)C)C
Molecular Formula
C13H14O5
Molecular Weight
250.25
Precautions
H301, H311, H331, H351
References & Citations
[1]de Oliveira Filho JWG, et al, A comprehensive review on biological properties of citrinin. Food Chem Toxicol. 2017 Dec;110:130-141.|[2]Islam MR, et al. Immune modulatory effects of the foodborne contaminant citrinin in mice. Food Chem Toxicol. 2012 Oct;50 (10) :3537-47.|[3]de Oliveira Filho JWG, et al. Citrinin against breast cancer: A cytogenotoxicological study. Phytother Res. 2021 Jan;35 (1) :504-516.|[4]Nakajima Y, et al. Low doses of the mycotoxin citrinin protect cortical neurons against glutamate-induced excitotoxicity. J Toxicol Sci. 2016 Apr;41 (2) :311-9.|[5]Wu Y, et al. Citrinin exposure affects oocyte maturation and embryo development by inducing oxidative stress-mediated apoptosis. Oncotarget. 2017 May 23;8 (21) :34525-34533.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Microbial Metabolite

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