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D-CopA3

CAT: 0804-HY-P10914Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-P10914Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
D-CopA3 is the inhibitor for MDM2 and the activator for p53 signaling pathway. D-CopA3 exhibits cytotoxicity in colorectal cancer cells HCT-116, LoVo, and RKO (IC50=15-18 μM), induces JNK/Beclin-1 mediated autophagy. D-CopA3 downregulates the expression of cell cycle inhibitory protein p21Cip1/Waf1, enhances the mucosal barrier function and reduces penetration of inflammatory mediators. D-CopA3 exhibits anti-inflammtory activity in mouse C. difficile toxin A-induced acute enteritis models and DSS -induced chronic colitis models. D-CopA3 exhibits antitumor efficacy in mouse HCT-116 xenograft models[1][2].
CAS Number
1426227-11-3
UNSPSC
12352209
Target
Autophagy; MDM-2/p53
Related Pathways
Apoptosis; Autophagy
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Smiles
NCCCC[C@H](C(N)=O)NC([C@@H](CCCCN)NC([C@@H](CCCNC(N)=N)NC([C@@H](CC(C)C)NC([C@@H](C)NC([C@@H]([C@H](C)CC)NC([C@@H](CSSC[C@@H](NC([C@@H](CC(C)C)NC([C@H](N)CC(C)C)=O)=O)C(N[C@H]([C@H](C)CC)C(N[C@H](C)C(N[C@H](CC(C)C)C(N[C@H](CCCNC(N)=N)C(N[C@H](CCCCN)C(N[C@@H](C(N)=O)CCCCN)=O)=O)=O)=O)=O)=O)NC([C@@H](CC(C)C)NC([C@H](N)CC(C)C)=O)=O)=O)=O)=O)=O)=O)=O
Molecular Formula
C96H184N30O18S2
Molecular Weight
2110.81
References & Citations
[1]Kim DH, et al., The Insect Peptide CopA3 Increases Colonic Epithelial Cell Proliferation and Mucosal Barrier Function to Prevent Inflammatory Responses in the Gut. J Biol Chem. 2016 Feb 12;291 (7) :3209-23.|[2]Dey DK, et al., CopA3 peptide inhibits MDM2-p53 complex stability in colorectal cancers and activates p53 mediated cell death machinery. Life Sci. 2023 Apr 1;318:121476.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

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