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D-CopA3

CAT: 0931-TP3127-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-TP3127-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1426227-11-3
Target
MDM-2/p53, Autophagy
Related Pathways
Autophagy, Apoptosis
Bioactivity
D-CopA3 is an inhibitor of MDM2 and an activator of the p53 signaling pathway. It exhibits cytotoxicity in colorectal cancer cells HCT-116, LoVo, and RKO with IC50 values of 15-18 μM and induces JNK/Beclin-1 mediated autophagy. D-CopA3 downregulates the expression of the cell cycle inhibitor protein p21Cip1/Waf1, enhances mucosal barrier function, and reduces infiltration of inflammatory mediators. It shows anti-inflammatory properties in mouse models of acute enteritis induced by C. difficile toxin A and chronic colitis induced by DSS. Additionally, D-CopA3 demonstrates antitumor activity in a mouse HCT-116 xenograft model.
Smiles
[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@H](CCCCN)C(N)=O)=O)CCCCN)=O)CCCNC(=N)N)=O)CC(C)C)=O)C)=O)[C@@H](CC)C)=O)(NC([C@H](NC([C@@H](CC(C)C)N)=O)CC(C)C)=O)CSSC[C@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@H](CCCCN)C(N)=O)=O)CCCCN)=O)CCCNC(=N)N)=O)CC(C)C)=O)C)=O)[C@@H](CC)C)=O)NC([C@H](NC([C@@H](CC(C)C)N)=O)CC(C)C)=O
Molecular Formula
C96H184N30O18S2
Molecular Weight
2110.81
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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