Pep2-SVKE

CAT: 0804-HY-P1055Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-P1055Size:1 Each
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Description
Pep2-SVKE is an inactive control peptide for pep2-SVKI (HY-P1056) . Pep2-SVKE is an inhibitory peptide corresponding to the last 10 amino acids of the C-terminus of the GluR2 AMPA receptor subunit. Pep2-SVKE does not block AMPA-mediated [3H]DA exocytosis. Pep2-SVKE does not bind to GRIP or PICK43 and does not block retention of PICK1 by GST-GluR2 and LTD[1][2][3][4][5].
CAS Number
[1315378-76-7]
UNSPSC
12352209
Target
IGluR
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Smiles
OC(C=C1)=CC=C1C[C@@H](C(NCC(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCC(O)=O)C(N[C@@H](CO)C(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(N[C@H](C(O)=O)CCC(O)=O)=O)=O)=O)=O)=O)=O)=O)NC([C@H](C(C)C)NC([C@H](CC(N)=O)NC([C@@H](N)CC2=CC=C(C=C2)O)=O)=O)=O
Molecular Formula
C59H89N13O20
Molecular Weight
1300.41
References & Citations
[1]Mameli M, et al. Rapid synthesis and synaptic insertion of GluR2 for mGluR-LTD in the ventral tegmental area. Science. 2007 Jul 27;317 (5837) :530-3.|[2]Liu SJ, et al. Subunit interaction with PICK and GRIP controls Ca2+ permeability of AMPARs at cerebellar synapses. Nat Neurosci. 2005 Jun;8 (6) :768-75.|[3]Grilli M, et al. In vitro exposure to nicotine induces endocytosis of presynaptic AMPA receptors modulating dopamine release in rat nucleus accumbens nerve terminals. Neuropharmacology. 2012 Oct;63 (5) :916-26. |[4]Pittaluga A, et al. Trafficking of presynaptic AMPA receptors mediating neurotransmitter release: neuronal selectivity and relationships with sensitivity to cyclothiazide. Neuropharmacology. 2006 Mar;50 (3) :286-96.|[5]Daw MI, et al. PDZ proteins interacting with C-terminal GluR2/3 are involved in a PKC-dependent regulation of AMPA receptors at hippocampal synapses. Neuron. 2000 Dec;28 (3) :873-86.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
AMPA Receptor

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