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Taspoglutide (acetate)

CAT: 0804-HY-P0165B-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P0165B-01Size:1 mg
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Description
Taspoglutide (R1583) acetate is an agonist of the glucagon-like peptide 1 receptor (GLP-1R) with an Ki value of 1.1 nM. Taspoglutide acetate induces cAMP accumulation in CHO-K1 cells expressing human GLP-1R (EC50 = 0.06 nM) . Taspoglutide acetate decreases blood levels of glucose and increases blood levels of insulin in a glucose tolerance test in Zucker diabetic obese rats. Taspoglutide acetate reduces blood levels of gastric inhibitory polypeptide (GIP), plasma levels of triglycerides, and body weight in the same model[1][2].
CAS Number
1022150-16-8
Product Name Alternative
ITM077 (acetate) ; R1583 (acetate) ; BIM51077 (acetate)
UNSPSC
12352209
Target
GLP Receptor
Related Pathways
GPCR/G Protein
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Smiles
N=C(NCCC[C@H](NC(C(C)(NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC1=CNC2=CC=CC=C12)NC([C@@H](NC([C@@H](NC([C@H](CC3=CC=CC=C3)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@H](CC4=CC=C(O)C=C4)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC5=CC=CC=C5)NC([C@@H](NC(CNC([C@@H](NC(C(C)(NC([C@H](CC6=CN=CN6)N)=O)C)=O)CCC(O)=O)=O)=O)[C@@H](C)O)=O)=O)[C@@H](C)O)=O)CO)=O)CC(O)=O)=O)C(C)C)=O)CO)=O)CO)=O)=O)CC(C)C)=O)CCC(O)=O)=O)=O)CCC(N)=O)=O)C)=O)C)=O)CCCCN)=O)CCC(O)=O)=O)=O)[C@H](CC)C)=O)C)=O)=O)CC(C)C)=O)C(C)C)=O)CCCCN)=O)C)=O)C(N)=O)N.CC(O)=O.[x]
Molecular Formula
C152H232N40O45.xC2H4O2
Molecular Weight
3339.71 (free base)
References & Citations
[1]Dong JZ, et al. Discovery and characterization of taspoglutide, a novel analogue of human glucagon-like peptide-1, engineered for sustained therapeutic activity in type 2 diabetes. Diabetes Obes Metab. 2011 Jan;13 (1) :19-25.|[2]Sebokova E, et al. Taspoglutide, a novel human once-weekly analogue of glucagon-like peptide-1, improves glucose homeostasis and body weight in the Zucker diabetic fatty rat. Diabetes Obes Metab. 2010 Aug;12 (8) :674-82.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
Phase 3

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