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YIGSR-Lys (N3)

CAT: 0804-HY-P0132ASize: 1 EachDry Ice: NoHazardous: No
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Description
YIGSR-Lys (N3) is a peptide that can inhibit the tumour growth and metastasis of leukaemic cells. YIGSR blocks the cellular binding to laminin I via a 67-kDa laminin-binding protein, and inhibits shear-induced increase in eNOS expression of laminin cells[1][2]. YIGSR-Lys (N3) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
CAS Number
2415188-59-7
UNSPSC
12352209
Target
NO Synthase
Related Pathways
Immunology/Inflammation
Field of Research
Cancer
Smiles
OC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](N)CC1=CC=C(O)C=C1)=O)[C@H](CC)C)=O)=O)CO)=O)CCCNC(N)=N)=O)CCCCN=[N+]=[N-])=O
Molecular Formula
C32H52N12O9
Molecular Weight
748.83
References & Citations
[1]N Yoshida, et al. The laminin-derived peptide YIGSR (Tyr–Ile–Gly–Ser–Arg) inhibits human pre-B leukaemic cell growth and dissemination to organs in SCID mice. Br J Cancer. 1999 Aug; 80 (12) : 1898–1904.|[2]Gloe T, et al. The 67-kDa laminin-binding protein is involved in shear stress-dependent endothelial nitric-oxide synthase expression. J Biol Chem. 1999 Jun 4;274 (23) :15996-6002.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

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