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YIGSR

CAT: 0804-HY-P0132-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P0132-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
YIGSR is a peptide that can inhibit the tumour growth and metastasis of leukaemic cells[1]. YIGSR blocks the cellular binding to laminin I via a 67-kDa laminin-binding protein, and inhibits shear-induced increase in eNOS expression of laminin cells[2].
CAS Number
110590-64-2
Product Name Alternative
Laminin Fragment 929-933
UNSPSC
12352209
Hazard Statement
H302-H315-H319-H335
Target
NO Synthase
Type
Peptides
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/yigsr.html
Purity
99.28
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
N=C(N)NCCC[C@@H](C(O)=O)NC([C@H](CO)NC(CNC([C@H]([C@@H](C)CC)NC([C@H](CC1=CC=C(C=C1)O)N)=O)=O)=O)=O
Molecular Formula
C26H42N8O8
Molecular Weight
594.66
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]N Yoshida, et al. The laminin-derived peptide YIGSR (Tyr–Ile–Gly–Ser–Arg) inhibits human pre-B leukaemic cell growth and dissemination to organs in SCID mice. Br J Cancer. 1999 Aug; 80 (12) : 1898–1904.|[2]Gloe T, et al. The 67-kDa laminin-binding protein is involved in shear stress-dependent endothelial nitric-oxide synthase expression. J Biol Chem. 1999 Jun 4;274 (23) :15996-6002.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported

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