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Malabaricone C (Standard)

CAT: 0804-HY-N8518RSize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-N8518RSize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Malabaricone C is an orally active and noncompetitive sphingomyelin synthase (SMS) inhibitor with IC50 values of 3 μM and 1.5 μM for SMS 1 and SMS 2, respectively. Malabaricone C reduces body weight gain, improves glucose tolerance, and decreases lipid accumulation in the liver, showing significant prevention of high fat diet-induced fatty liver in mice. Malabaricone C has anti-inflammatory effects, which is found in the fruits of Myristica cinnamomea King. Malabaricone C is promising for research of obesity and immunological disorders caused due to hyper-activation of T-cells[1][2][3].
CAS Number
[63335-25-1]
UNSPSC
12352005
Target
Apoptosis; NF-κB; p38 MAPK; Phospholipase
Related Pathways
Apoptosis; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB
Field of Research
Cancer; Metabolic Disease; Inflammation/Immunology
Smiles
O=C(C1=C(O)C=CC=C1O)CCCCCCCCC2=CC=C(O)C(O)=C2
Molecular Formula
C21H26O5
Molecular Weight
358.43
References & Citations
[1]Othman MA, et al. Malabaricone C as Natural Sphingomyelin Synthase Inhibitor against Diet-Induced Obesity and Its Lipid Metabolism in Mice. ACS Med Chem Lett. 2019;10 (8) :1154-1158. Published 2019 Jul 3.|[2]Patwardhan RS, et al. Malabaricone C, a constituent of spice Myristica malabarica, exhibits anti-inflammatory effects via modulation of cellular redox. J Biosci. 2023;48 (2) :9.|[3]Tyagi M, et al. Mechanism of the malabaricone C-induced toxicity to the MCF-7 cell line. Free Radic Res. 2014 Apr;48 (4) :466-77.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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