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7,4'-Dihydroxyflavone (Standard)

CAT: 0804-HY-N2609R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N2609R-01Size:5 mg
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Description
7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid, which can be isolated from Glycyrrhiza uralensis. 7,4'-Dihydroxyflavone is eotaxin/CCL11 inhibitor and CBR1 inhibitor (IC50=0.28 μM) . 7,4'-Dihydroxyflavone has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex) ‐paradoxical adverse effects on eotaxin production[1]. 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2.7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC50 value of 1.4 µM[1].
CAS Number
2196-14-7
UNSPSC
12352005
Target
CCR; COX; NF-κB
Related Pathways
GPCR/G Protein; Immunology/Inflammation; NF-κB
Field of Research
Inflammation/Immunology; Endocrinology
Smiles
O=C1C=C(C2=CC=C(O)C=C2)OC3=CC(O)=CC=C13
Molecular Formula
C15H10O4
Molecular Weight
254.24
References & Citations
[1]Liu C, et al. The Flavonoid 7,4'-Dihydroxyflavone Prevents Dexamethasone Paradoxical Adverse Effect on Eotaxin Production by Human Fibroblasts. Phytother Res. 2017 Mar;31 (3) :449-458.|[2]Arai Y, et al. Structure-activity relationship of flavonoids as potent inhibitors of carbonyl reductase 1 (CBR1) . Fitoterapia. 2015 Mar;101:51-6.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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