Phomopsin D

• Description :

  Phomopsin D, a mycotoxin, is a derivative of Phomopsin A (HY-N6793) . Phomopsin A is a cyclic hexapeptide mycotoxin isolated from the fungus Phomopsis leptostomiformis. Phomopsin A is a noncompetitive inhibitor of the binding of radiolabeled vincristine to tubulin[1][2].

• UNSPSC :

  12352211

• Target :

  Drug Derivative

• Related Pathways :

  Others

• Field of Research :

  Others

• Smiles :

  O=C(N[C@H]1C(C)=C)[C@@H](NC)[C@@H](O)C2=CC(Cl)=C(O)C(O[C@](C)(CC)[C@@H](C(N3[C@@](C(N/C(C(NC(CC(O)=O)C(O)=O)=O)=C(C)/CC)=O)([H])C=CC3)=O)NC1=O)=C2

• Molecular Formula :

  C36H47ClN6O12

• Molecular Weight :

  791.24

• References & Citations :

  [1]Hamel E. Natural products which interact with tubulin in the vinca domain: maytansine, rhizoxin, phomopsin A, dolastatins 10 and 15 and halichondrin B. Pharmacol Ther. 1992;55 (1) :31-51.|[2]Sogahata K, et al. Biosynthetic Studies of Phomopsins Unveil Posttranslational Installation of Dehydroamino Acids by UstYa Family Proteins. Angew Chem Int Ed Engl. 2021 Dec 1;60 (49) :25729-25734.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• CAS Number :

  [175617-09-1]