Phomopsin D

CAT: 0804-HY-N16440Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-N16440Size:1 Each
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Description
Phomopsin D, a mycotoxin, is a derivative of Phomopsin A (HY-N6793) . Phomopsin A is a cyclic hexapeptide mycotoxin isolated from the fungus Phomopsis leptostomiformis. Phomopsin A is a noncompetitive inhibitor of the binding of radiolabeled vincristine to tubulin[1][2].
CAS Number
[175617-09-1]
UNSPSC
12352211
Target
Drug Derivative
Related Pathways
Others
Field of Research
Others
Smiles
O=C(N[C@H]1C(C)=C)[C@@H](NC)[C@@H](O)C2=CC(Cl)=C(O)C(O[C@](C)(CC)[C@@H](C(N3[C@@](C(N/C(C(NC(CC(O)=O)C(O)=O)=O)=C(C)/CC)=O)([H])C=CC3)=O)NC1=O)=C2
Molecular Formula
C36H47ClN6O12
Molecular Weight
791.24
References & Citations
[1]Hamel E. Natural products which interact with tubulin in the vinca domain: maytansine, rhizoxin, phomopsin A, dolastatins 10 and 15 and halichondrin B. Pharmacol Ther. 1992;55 (1) :31-51.|[2]Sogahata K, et al. Biosynthetic Studies of Phomopsins Unveil Posttranslational Installation of Dehydroamino Acids by UstYa Family Proteins. Angew Chem Int Ed Engl. 2021 Dec 1;60 (49) :25729-25734.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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