Phomopsin A

• Description :

  Phomopsin A is a cyclic hexapeptide mycotoxin isolated from the fungus Phomopsis leptostomiformis. Phomopsin A is a noncompetitive inhibitor of the binding of radiolabeled vincristine to tubulin[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319, H335

• Target :

  Microtubule/Tubulin

• Type :

  Natural Products

• Related Pathways :

  Cell Cycle/DNA Damage; Cytoskeleton

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/phomopsin-a.html

• Purity :

  99.35

• Solubility :

  DMSO : 10 mg/mL (ultrasonic; warming)

• Smiles :

  O=C([C@H](N1)[C@](C)(OC2=CC([C@H](O)[C@H](NC)C(N[C@@H](C(C)=C)C1=O)=O)=CC(Cl)=C2O)CC)N3[C@@H](C=CC3)C(N/C(C(N/C(C(O)=O)=C/C(O)=O)=O)=C(C)/CC)=O

• Molecular Formula :

  C36H45ClN6O12

• Molecular Weight :

  789.23

• Precautions :

  H315, H319, H335

• References & Citations :

  [1]Hamel E, et al. Natural products which interact with tubulin in the vinca domain: maytansine, rhizoxin, phomopsin A, dolastatins 10 and 15 and halichondrin B. Pharmacol Ther. 1992;55 (1) :31-51.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• CAS Number :

  [64925-80-0]