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Phomopsin A

CAT: 0804-HY-N6793Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N6793Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Phomopsin A is a cyclic hexapeptide mycotoxin isolated from the fungus Phomopsis leptostomiformis. Phomopsin A is a noncompetitive inhibitor of the binding of radiolabeled vincristine to tubulin[1].
CAS Number
64925-80-0
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Microtubule/Tubulin
Type
Natural Products
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/phomopsin-a.html
Purity
99.35
Solubility
DMSO : 10 mg/mL (ultrasonic; warming)
Smiles
O=C([C@H](N1)[C@](C)(OC2=CC([C@H](O)[C@H](NC)C(N[C@@H](C(C)=C)C1=O)=O)=CC(Cl)=C2O)CC)N3[C@@H](C=CC3)C(N/C(C(N/C(C(O)=O)=C/C(O)=O)=O)=C(C)/CC)=O
Molecular Formula
C36H45ClN6O12
Molecular Weight
789.23
Precautions
H315, H319, H335
References & Citations
[1]Hamel E, et al. Natural products which interact with tubulin in the vinca domain: maytansine, rhizoxin, phomopsin A, dolastatins 10 and 15 and halichondrin B. Pharmacol Ther. 1992;55 (1) :31-51.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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