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Disorazol A

CAT: 0804-HY-N14734Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-N14734Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Disorazol A1 is an tubulin inhibitor with antifungal activity. Disorazol A1 functions by inhibiting tubulin polymerization, interfering with microtubule formation, blocking mitosis, thus arresting the cell cycle at the G2/M phase and inducing apoptosis. Disorazol A1 also exhibits an inhibitory effect against L929 mouse fibroblasts with an IC50 value of 3 pM. Disorazol A1 causes the accumulation of p53 protein in the cell nucleus. Disorazol A1 is promising for research of cancers[1].
CAS Number
158181-47-6
UNSPSC
12352005
Target
Apoptosis; Fungal; Microtubule/Tubulin; Mitosis
Related Pathways
Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(C1=COC(C[C@@H](OC)C=CC=CC=CC[C@@H](C(C)(C)[C@@H](O)/C=C/C)OC2=O)=N1)O[C@H](C(C)(C)[C@@H](O)/C=C/C)CC=C[C@@]3([H])O[C@@]3([H])C=CC=CC4=NC2=CO4
Molecular Formula
C43H54N2O10
Molecular Weight
758.90
References & Citations
[1]Elnakady YA, et al. Disorazol A1, a highly effective antimitotic agent acting on tubulin polymerization and inducing apoptosis in mammalian cells. Biochem Pharmacol. 2004 Mar 1;67 (5) :927-35.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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CatalogName
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