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Disorazol A

CAT: 0931-TN10381-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-TN10381-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
158181-47-6
Target
Apoptosis, Antifungal, Microtubule Associated
Related Pathways
Cytoskeletal Signaling, Apoptosis, Microbiology/Virology
Bioactivity
Disorazol A1 is a tubulin inhibitor with antifungal properties. It functions by inhibiting tubulin polymerization and disrupting microtubule formation, thereby blocking mitosis and arresting the cell cycle at the G2/M phase, which induces apoptosis. Disorazol A1 also inhibits L929 mouse fibroblasts with an IC50 value of 3 pm and causes accumulation of p53 protein in the nucleus. Disorazol A1 holds potential for cancer research.
Smiles
C/C=C/[C@@H](C(C)(C)[C@@H]1C/C=C\C=C/C=C\[C@@H](CC2=NC(=CO2)C(=O)O[C@@H](C/C=C\[C@@H]3[C@@H](O3)/C=C\C=C/C4=NC(=CO4)C(=O)O1)C(C)(C)[C@H](/C=C/C)O)OC)O
Molecular Formula
C43H54N2O10
Molecular Weight
758.896
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
HY-N14734Disorazol A

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