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8-Deoxylactucin

CAT: 0804-HY-N12087Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N12087Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
8-Deoxylactucin is an orally active sesquiterpene lactone. 8-Deoxylactucin inhibits LPS -induced NO production in RAW264.7 macrophages with an IC50 value of 4.35 μM. 8-Deoxylactucin exerts anti-inflammatory effects by blocking the NF-κB pathway. 8-Deoxylactucin demonstrates hepatoprotective efficacy in LPS/D-galactosamine-induced acute hepatitis model of mice. 8-Deoxylactucin can be used for the study of inflammatory diseases and inflammatory liver injuries[1].
CAS Number
65725-10-2
UNSPSC
12352005
Target
NF-κB; NO Synthase; Reactive Oxygen Species (ROS)
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Field of Research
Inflammation/Immunology
Smiles
OCC([C@]1([H])[C@]2([H])[C@](CCC(C)=C13)([H])C(C(O2)=O)=C)=CC3=O
Molecular Formula
C15H16O4
Molecular Weight
260.29
References & Citations
[1]Zhou Y, et al. Sesquiterpene lactones from Cichorium intybus exhibit potent anti-inflammatory and hepatoprotective effects by repression of NF-κB and enhancement of NRF2. J Ethnopharmacol. 2025 Mar 13;343:119439.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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