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Dihydromyricetin-d4

CAT: 0804-HY-N0112SSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-N0112SSize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Dihydromyricetin-d4 (Ampelopsin-d4) is deuterium labeled Dihydromyricetin. Dihydromyricetin is a potent inhibitor with an IC50 of 48 μM on dihydropyrimidinase. Dihydromyricetin can activate autophagy through inhibiting mTOR signaling. Dihydromyricetin suppresses the formation of mTOR complexes (mTORC1/2) . Dihydromyricetin is also a potent influenza RNA-dependent RNA polymerase inhibitor with an IC50 of 22 μM.
Product Name Alternative
Ampelopsin-d4; Ampeloptin-d4
UNSPSC
12352005
Target
Autophagy; DNA/RNA Synthesis; Influenza Virus; Isotope-Labeled Compounds; mTOR
Related Pathways
Anti-infection; Autophagy; Cell Cycle/DNA Damage; Others; PI3K/Akt/mTOR
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection
Smiles
O=C1C2=C(O)C([2H])=C(O)C([2H])=C2O[C@H](C3=C([2H])C(O)=C(C(O)=C3[2H])O)[C@H]1O
Molecular Formula
C15H8D4O8
Molecular Weight
324.28
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Václav Zima, et al. Unraveling the Anti-Influenza Effect of Flavonoids: Experimental Validation of Luteolin and its Congeners as Potent Influenza Endonuclease Inhibitors. Eur J Med Chem. 22 August 2020, 112754.|[3]Chang H, et al. Ampelopsin suppresses breast carcinogenesis by inhibiting the mTOR signalling pathway. Carcinogenesis. 2014 Aug;35 (8) :1847-54.|[4]Huang CY. Inhibition of a Putative Dihydropyrimidinase from Pseudomonas aeruginosa PAO1 by Flavonoids and Substrates of Cyclic Amidohydrolases. PLoS One. 2015 May 19;10 (5) :e0127634.|[5]Kou X, et al. Ampelopsin attenuates brain aging of D-gal-induced rats through miR-34a-mediated SIRT1/mTORsignal pathway. Oncotarget. 2016 Nov 15;7 (46) :74484-74495.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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