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Bepotastine (Standard)

CAT: 0804-HY-I0021R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-I0021R-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Bepotastine (Standard) is the analytical standard of Bepotastine. This product is intended for research and analytical applications. Bepotastine is a selective and orally active second-generation histamine H1 receptor antagonist, can suppress the expression of nerve growth factor (NGF) . Bepotastine has the potential for allergic rhinitis, allergic conjunctivitis and urticaria/pruritus research[1][2][3][4].
CAS Number
125602-71-3
UNSPSC
12352100
Target
Histamine Receptor; Reference Standards
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling; Others
Field of Research
Endocrinology; Inflammation/Immunology
Smiles
O=C(O)CCCN1CCC(O[C@@H](C2=CC=C(Cl)C=C2)C3=CC=CC=N3)CC1
Molecular Formula
C21H25ClN2O3
Molecular Weight
388.89
References & Citations
[1]Jon I Williams, et al. Non-clinical pharmacology, pharmacokinetics, and safety findings for the antihistamine bepotastine besilate. Curr Med Res Opin. 2010 Oct;26 (10) :2329-38.|[2]Kida T, et al. Bepotastine besilate, a highly selective histamine H (1) receptor antagonist, suppresses vascular hyperpermeability and eosinophil recruitment in in vitro and in vivo experimental allergic conjunctivitis models. Exp Eye Res. 2010 Jul;91 (1) :85-91. |[3]Tanizaki H, et al. Oral administration of bepotastine besilate suppressed scratching behavior of atopic dermatitis model NC/Nga mice. Int Arch Allergy Immunol. 2008;145 (4) :277-82.|[4]Kamata Y, et al. Bepotastine besilate downregulates the expression of nerve elongation factors in normal human epidermal keratinocytes. J Dermatol Sci. 2018 Apr 23:S0923-1811 (18) 30186-5.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Clinical Information
Launched

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