Bepotastine

• Description:

  Bepotastine is a selective and orally active second-generation histamine H1 receptor antagonist, can suppress the expression of nerve growth factor (NGF) . Bepotastine has the potential for allergic rhinitis, allergic conjunctivitis and urticaria/pruritus research[1][2][3][4].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H312, H332

• Target:

  Histamine Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Endocrinology; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/bepotastine.html

• Purity:

  98.58

• Solubility:

  DMSO : 100 mg/mL (ultrasonic) |H2O : ≥ 100 mg/mL

• Smiles:

  O=C (O) CCCN1CCC (O[C@@H] (C2=CC=C (Cl) C=C2) C3=CC=CC=N3) CC1

• Molecular Formula:

  C21H25ClN2O3

• Molecular Weight:

  388.89

• Precautions:

  H302, H312, H332

• References & Citations:

  [1]Jon I Williams, et al. Non-clinical pharmacology, pharmacokinetics, and safety findings for the antihistamine bepotastine besilate. Curr Med Res Opin. 2010 Oct;26 (10) :2329-38.|[2]Kida T, et al. Bepotastine besilate, a highly selective histamine H (1) receptor antagonist, suppresses vascular hyperpermeability and eosinophil recruitment in in vitro and in vivo experimental allergic conjunctivitis models. Exp Eye Res. 2010 Jul;91 (1) :85-91. |[3]Tanizaki H, et al. Oral administration of bepotastine besilate suppressed scratching behavior of atopic dermatitis model NC/Nga mice. Int Arch Allergy Immunol. 2008;145 (4) :277-82.|[4]Kamata Y, et al. Bepotastine besilate downregulates the expression of nerve elongation factors in normal human epidermal keratinocytes. J Dermatol Sci. 2018 Apr 23:S0923-1811 (18) 30186-5.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• Isoform:

  H1 Receptor

• CAS Number:

  125602-71-3