BC-GLA-NHS

CAT: 0804-HY-D2956Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-D2956Size:1 Each
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Description
BC-GLA-NHS (CLIP-GLA-NHS) is a NHS-labeled CLIP tag, which is an amine-reactive crosslinker and can achieve site-specific protein labeling. The NHS ester of BC-GLA-NHS reacts with the primary amine of the target molecule (such as antibodies, quantum dots) in a pH 7.5-8.5 buffer solution to form a stable amide bond. After coupling, the BC molecule undergoes a nucleophilic substitution reaction with the active site (Cys) of the CLIP-tagged fusion protein, releasing benzylcytosine and forming an irreversible thioether bond, achieving covalent labeling. BC-GLA-NHS can be used for click chemistry labeling[1].
Product Name Alternative
CLIP-GLA-NHS
UNSPSC
12352005
Target
Biochemical Assay Reagents
Related Pathways
Others
Field of Research
Others
Smiles
NC1=CC=NC(OCC2=CC=C(C=C2)CNC(CCCC(ON3C(CCC3=O)=O)=O)=O)=N1
Molecular Formula
C21H23N5O6
Molecular Weight
441.44
References & Citations
[1]Corrêa IR Jr. Considerations and protocols for the synthesis of custom protein labeling probes. Methods Mol Biol. 2015;1266:55-79.
Shipping Conditions
Room temperature
Scientific Category
Dye Reagents
Clinical Information
No Development Reported

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