BC-GLA-NHS

• Description:

  BC-GLA-NHS (CLIP-GLA-NHS) is a NHS-labeled CLIP tag, which is an amine-reactive crosslinker and can achieve site-specific protein labeling. The NHS ester of BC-GLA-NHS reacts with the primary amine of the target molecule (such as antibodies, quantum dots) in a pH 7.5-8.5 buffer solution to form a stable amide bond. After coupling, the BC molecule undergoes a nucleophilic substitution reaction with the active site (Cys) of the CLIP-tagged fusion protein, releasing benzylcytosine and forming an irreversible thioether bond, achieving covalent labeling. BC-GLA-NHS can be used for click chemistry labeling[1].

• Product Name Alternative:

  CLIP-GLA-NHS

• UNSPSC:

  12352005

• Target:

  Biochemical Assay Reagents

• Related Pathways:

  Others

• Field of Research:

  Others

• Smiles:

  NC1=CC=NC(OCC2=CC=C(C=C2)CNC(CCCC(ON3C(CCC3=O)=O)=O)=O)=N1

• Molecular Formula:

  C21H23N5O6

• Molecular Weight:

  441.44

• References & Citations:

  [1]Corrêa IR Jr. Considerations and protocols for the synthesis of custom protein labeling probes. Methods Mol Biol. 2015;1266:55-79.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Dye Reagents

• Clinical Information:

  No Development Reported