Phloretin

• Description :

  Phloretin (NSC 407292; RJC 02792) is a flavonoid extracted from Malus pumila Mill., has anti-inflammatory activities. Phloridzin is a specific, competitive and orally active inhibitor of sodium/glucose cotransporters in the intestine (SGLT1) and kidney (SGLT2) . Phloretin inhibits Yeast-made GLUT1 as well as Human erythrocyte GLUT1 with IC50values of 49 μM and 61 μM, respectively[1].Phloretin has the potential for the treatment of rheumatoid arthritis (RA) and allergic airway inflammation[4].

• Product Name Alternative :

  NSC 407292; RJC 02792

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Endogenous Metabolite; GLUT; SGLT

• Type :

  Natural Products

• Related Pathways :

  Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Metabolic Disease; Cancer

• Assay Protocol :

  https://www.medchemexpress.com/phloretin.html

• Purity :

  99.92

• Solubility :

  DMSO : 50 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic)

• Smiles :

  O=C(C1=C(O)C=C(O)C=C1O)CCC2=CC=C(O)C=C2

• Molecular Formula :

  C15H14O5

• Molecular Weight :

  274.27

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1] Kasahara T, Kasahara M. Expression of the rat GLUT1 glucose transporter in the yeast Saccharomyces cerevisiae. Biochem J. 1996 Apr 1;315 (Pt 1) :177-82.|[2]Luo H, et al. Phloretin induces apoptosis of BEL-7402 cells in vitro. Nan Fang Yi Ke Da Xue Xue Bao. 2008 Jul;28 (7) :1249-51.|[3]Huang WC, et al. Phloretin and phlorizin promote lipolysis and inhibit inflammation in mouse 3T3-L1 cells and in macrophage-adipocyte co-cultures.Mol Nutr Food Res. 2013 Oct;57 (10) :1803-13.|[4]Wang SP, et al. Potent Antiarthritic Properties of Phloretin in Murine Collagen-Induced Arthritis.Evid Based Complement Alternat Med. 2016;2016:9831263.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• Isoform :

  GLUT1; GLUT2; Microbial Metabolite; SGLT1; SGLT2

• CAS Number :

  [60-82-2]