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Phloretin

CAT: 0804-HY-N0142-01Size: 250 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N0142-01Size:250 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Phloretin (NSC 407292; RJC 02792) is a flavonoid extracted from Malus pumila Mill., has anti-inflammatory activities. Phloridzin is a specific, competitive and orally active inhibitor of sodium/glucose cotransporters in the intestine (SGLT1) and kidney (SGLT2) . Phloretin inhibits Yeast-made GLUT1 as well as Human erythrocyte GLUT1 with IC50values of 49 μM and 61 μM, respectively[1].Phloretin has the potential for the treatment of rheumatoid arthritis (RA) and allergic airway inflammation[4].
CAS Number
60-82-2
Product Name Alternative
NSC 407292; RJC 02792
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Endogenous Metabolite; GLUT; SGLT
Type
Natural Products
Related Pathways
Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Metabolic Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/phloretin.html
Purity
99.92
Solubility
DMSO : 50 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic)
Smiles
O=C(C1=C(O)C=C(O)C=C1O)CCC2=CC=C(O)C=C2
Molecular Formula
C15H14O5
Molecular Weight
274.27
Precautions
H302, H315, H319, H335
References & Citations
[1] Kasahara T, Kasahara M. Expression of the rat GLUT1 glucose transporter in the yeast Saccharomyces cerevisiae. Biochem J. 1996 Apr 1;315 (Pt 1) :177-82.|[2]Luo H, et al. Phloretin induces apoptosis of BEL-7402 cells in vitro. Nan Fang Yi Ke Da Xue Xue Bao. 2008 Jul;28 (7) :1249-51.|[3]Huang WC, et al. Phloretin and phlorizin promote lipolysis and inhibit inflammation in mouse 3T3-L1 cells and in macrophage-adipocyte co-cultures.Mol Nutr Food Res. 2013 Oct;57 (10) :1803-13.|[4]Wang SP, et al. Potent Antiarthritic Properties of Phloretin in Murine Collagen-Induced Arthritis.Evid Based Complement Alternat Med. 2016;2016:9831263.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
GLUT1; GLUT2; Microbial Metabolite; SGLT1; SGLT2

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