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Phlorizin

CAT: 0804-HY-N0143-01Size: 500 mgDry Ice: NoHazardous: No
CAT#:0804-HY-N0143-01Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Phlorizin (Floridzin) is a non-selective SGLT inhibitor with Kis of 300 and 39 nM for hSGLT1 and hSGLT2, respectively. Phlorizin is also a Na+/K+-ATPase inhibitor.
CAS Number
[60-81-1]
Product Name Alternative
Floridzin
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Na+/K+ ATPase; SGLT
Type
Natural Products
Related Pathways
Membrane Transporter/Ion Channel
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/Phlorizin.html
Concentration
10mM
Purity
99.93
Solubility
DMSO : ≥ 50 mg/mL|H2O : 1 mg/mL (ultrasonic)
Smiles
O=C(C1=C(O)C=C(O)C=C1O[C@H]2[C@@H]([C@H]([C@@H]([C@@H](CO)O2)O)O)O)CCC3=CC=C(O)C=C3
Molecular Formula
C21H24O10
Molecular Weight
436.41
Precautions
H302, H315, H319, H335
References & Citations
[1]Pajor AM, et al. Inhibitor binding in the human renal low- and high-affinity Na+/glucose cotransporters. J Pharmacol Exp Ther. 2008 Mar;324 (3) :985-91.|[2]Nakagawa A, et al. Localization of the phlorizin site on Na, K-ATPase in red cell membranes. J Biochem. 1977 May;81 (5) :1511-5.|[3]Chang WT, et al. Evaluation of the anti-inflammatory effects of phloretin and phlorizin in lipopolysaccharide-stimulated mouse macrophages. Food Chem. 2012 Sep 15;134 (2) :972-9.|[4]Katsuda Y, et al. Contribution of hyperglycemia on diabetic complications in obese type 2 diabetic SDT fatty rats: effects of SGLT inhibitor phlorizin. Exp Anim. 2015;64 (2) :161-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
SGLT1; SGLT2

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