Thiethylperazine-d3

• Description:

  Thiethylperazine-d3 is the deuterium labeled Thiethylperazinee (HY-B1794) . Thiethylperazine, a phenothiazine derivate, is an orally active and potent dopamine D2-receptor and histamine H1-receptor antagonist. Thiethylperazine is also a selective ABCC1activator that reduces amyloid-β (Aβ) load in mice. Thiethylperazine has anti-emetic, antipsychotic and antimicrobial effects[1][2][3].

• UNSPSC:

  12352005

• Target:

  Amyloid-β; Bacterial; Dopamine Receptor; Histamine Receptor; Isotope-Labeled Compounds

• Related Pathways:

  Anti-infection; GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling; Others

• Field of Research:

  Infection; Neurological Disease

• Smiles:

  CCSC(C=C1N2CCCN3CCN(C([2H])([2H])[2H])CC3)=CC=C1SC4=C2C=CC=C4

• Molecular Formula:

  C22H26D3N3S2

• Molecular Weight:

  402.63

• References & Citations:

  [1]Czeizel AE, et al. Case-control study of teratogenic potential of thiethylperazine, an anti-emetic drug. BJOG. 2003 May;110 (5) :497-9. |[2]Krohn M, et al. Cerebral amyloid-β proteostasis is regulated by the membrane transport protein ABCC1 in mice. J Clin Invest. 2011 Oct;121 (10) :3924-31. |[3]Rahbar M, et al. Enhancement of vancomycin activity by phenothiazines against vancomycin-resistant Enterococcus faecium in vitro. Basic Clin Pharmacol Toxicol. 2010 Aug;107 (2) :676-9.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported