Thiethylperazine (Standard)

CAT: 0804-HY-B1794R-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B1794R-01Size:1 mg
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Description
Thiethylperazine (Standard) is the analytical standard of Thiethylperazine. This product is intended for research and analytical applications. Thiethylperazine, a phenothiazine derivate, is an orally active and potent dopamine D2-receptor and histamine H1-receptor antagonist. Thiethylperazine is also a selective ABCC1activator that reduces amyloid-β (Aβ) load in mice. Thiethylperazine has anti-emetic, antipsychotic and antimicrobial effects[1][2][3].
CAS Number
[1420-55-9]
UNSPSC
12352100
Target
Amyloid-β; Bacterial; Dopamine Receptor; Histamine Receptor; Reference Standards
Related Pathways
Anti-infection; GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling; Others
Field of Research
Infection; Neurological Disease
Smiles
CN1CCN(CCCN2C3=C(C=CC=C3)SC4=CC=C(SCC)C=C24)CC1
Molecular Formula
C22H29N3S2
Molecular Weight
399.62
References & Citations
[1]Czeizel AE, et al. Case-control study of teratogenic potential of thiethylperazine, an anti-emetic drug. BJOG. 2003 May;110 (5) :497-9.|[2]Krohn M, et al. Cerebral amyloid-β proteostasis is regulated by the membrane transport protein ABCC1 in mice. J Clin Invest. 2011 Oct;121 (10) :3924-31.|[3]Rahbar M, et al. Enhancement of vancomycin activity by phenothiazines against vancomycin-resistant Enterococcus faecium in vitro. Basic Clin Pharmacol Toxicol. 2010 Aug;107 (2) :676-9.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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