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Chlorphenoxamine (hydrochloride)

CAT: 0804-HY-B1607ASize: 1 EachDry Ice: NoHazardous: No
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Description
Chlorphenoxamine hydrochloride, an antihistamine and anticholinergic agent is a GPCR antagonist. Chlorphenoxamine hydrochloride inhibits multiple lethal viral diseases, such as SARS-CoV, MERS-CoV, EBOV and malaria. Chlorphenoxamine hydrochloride shows anti-filovirus activity against both EBOV and Marburg virus (MARV) with IC50s of 1.1 μM and 6.2 μM, respectively. Chlorphenoxamine hydrochloride is used for allergic conditions, urticaria, viral diseases and Parkinson’s disease[1][2][3][4][5].
CAS Number
562-09-4
UNSPSC
12352005
Hazard Statement
H302
Target
Filovirus; Histamine Receptor; Parasite; SARS-CoV
Related Pathways
Anti-infection; GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Field of Research
Infection; Neurological Disease; Inflammation/Immunology
Smiles
CC(C1=CC=CC=C1)(C2=CC=C(Cl)C=C2)OCCN(C)C.Cl
Molecular Formula
C18H23Cl2NO
Molecular Weight
340.29
Precautions
P264-P270-P330-P501
References & Citations
[1]ULDALL PR, et al. Chlorphenoxamine hydrochloride in parkinsonism. A controlled trial. Br Med J. 1961 Jun 10;1 (5240) :1649-52.|[2]BAZEX A, et al. Trial treatment of urticaria with chlorphenoxamine. Clinique (Paris) . 1963 Jul-Aug;58:447-50. |[3]Schafer A, et al. Repurposing potential of 1st generation H1-specific antihistamines as anti-filovirus therapeutics. Antiviral Res. 2018 Sep;157:47-56. |[4]Ashraf A, et al. Novel RP-HPLC-DAD approach for simultaneous determination of chlorphenoxamine hydrochloride and caffeine with their related substances. BMC Chem. 2024;18 (1) :133. Published 2024 Jul 19. |[5]Ashraf A, et al. Smart green spectrophotometric estimation and content uniformity testing of chlorphenoxamine HCl and caffeine in bulk forms and combined pharmaceutical formulation. Sci Rep. 2025;15 (1) :9482. Published 2025 Mar 19.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched

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