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Chlorphenoxamine

CAT: 0804-HY-B1607-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B1607-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Chlorphenoxamine, an antihistamine and anticholinergic agent is a GPCR antagonist. Chlorphenoxamine inhibits multiple lethal viral diseases, such as SARS-CoV, MERS-CoV, EBOV and malaria. Chlorphenoxamine shows anti-filovirus activity against both EBOV and Marburg virus (MARV)   with IC50s of 1.1 μM and 6.2 μM, respectively. Chlorphenoxamine is used for allergic conditions, urticaria, viral diseases and Parkinson’s disease[1][2][3][4][5].
CAS Number
[77-38-3]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Filovirus; Histamine Receptor; Parasite; SARS-CoV
Type
Reference compound
Related Pathways
Anti-infection; GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Infection; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Chlorphenoxamine.html
Purity
99.20
Solubility
DMSO : ≥ 48 mg/mL
Smiles
CN(CCOC(C1=CC=CC=C1)(C2=CC=C(C=C2)Cl)C)C
Molecular Formula
C18H22ClNO
Molecular Weight
303.83
Precautions
H302, H315, H319, H335
References & Citations
[1]Ashraf A, et al. Novel RP-HPLC-DAD approach for simultaneous determination of chlorphenoxamine hydrochloride and caffeine with their related substances. BMC Chem. 2024;18 (1) :133. Published 2024 Jul 19.|[2]Ashraf A, et al. Smart green spectrophotometric estimation and content uniformity testing of chlorphenoxamine HCl and caffeine in bulk forms and combined pharmaceutical formulation. Sci Rep. 2025;15 (1) :9482. Published 2025 Mar 19.|[3]BAZEX A, et al. Trial treatment of urticaria with chlorphenoxamine. Clinique (Paris) . 1963 Jul-Aug;58:447-50.|[4]ULDALL PR, et al. Chlorphenoxamine hydrochloride in parkinsonism. A controlled trial. Br Med J. 1961 Jun 10;1 (5240) :1649-52.|[5]Schafer A, et al. Repurposing potential of 1st generation H1-specific antihistamines as anti-filovirus therapeutics. Antiviral Res. 2018 Sep;157:47-56.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

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