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Bendroflumethiazide

CAT: 0804-HY-B1363-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B1363-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Bendroflumethiazide (Bendrofluazide) is an orally available diuretic. Bendroflumethiazide inhibits the electroneutral sodium-chloride symporter located in the apical membrane of the early segment of the distal convoluted tubule and can effectively lower blood pressure. Bendroflumethiazide is used in the study of hypertension and edema. Bendroflumethiazide has an antidiuretic effect in diabetes insipidus[1][2].
CAS Number
73-48-3
Product Name Alternative
Bendrofluazide
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
NKCC
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/bendroflumethiazide.html
Purity
99.16
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=S(C1=C(C(F)(F)F)C=C(C2=C1)NC(CC3=CC=CC=C3)NS2(=O)=O)(N)=O
Molecular Formula
C15H14F3N3O4S2
Molecular Weight
421.41
Precautions
H315, H319, H320
References & Citations
[1]Tamargo J, et al. Diuretics in the treatment of hypertension. Part 1: thiazide and thiazide-like diuretics. Expert Opin Pharmacother. 2014 Mar;15 (4) :527-47.|[2]Grønbeck L, et al. Mechanism of antidiuresis caused by bendroflumethiazide in conscious rats with diabetes insipidus. Br J Pharmacol. 1998 Feb;123 (4) :737-45.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

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