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Nitroxoline-d5

CAT: 0804-HY-B1159S1Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-B1159S1Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Nitroxoline-d5 (8-Hydroxy-5-nitroquinoline-d5) is deuterium labeled Nitroxoline. Nitroxoline (8-Hydroxy-5-nitroquinoline), an antibiotic, is an orally active antibiofilm agent. Nitroxoline reduces the formation and induces the dispersal of Pseudomonas aeruginosa biofilms by chelation of iron and zinc. Nitroxoline can be used for the urinary tract infections and cancer research[1][2][3].
Product Name Alternative
8-Hydroxy-5-nitroquinoline-d5; 5-Nitro-8-quinolinol-d5
UNSPSC
12352005
Target
Antibiotic; Apoptosis; Autophagy; Bacterial; Isotope-Labeled Compounds
Related Pathways
Anti-infection; Apoptosis; Autophagy; Others
Applications
COVID-19-immunoregulation
Field of Research
Infection; Cancer
Smiles
OC1=C2N=C(C([2H])=C(C2=C(C([2H])=C1[2H])[N+]([O-])=O)[2H])[2H]
Molecular Formula
C9HD5N2O3
Molecular Weight
195.19
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Jin-Guo Yu, et al. Nitroxoline induces cell apoptosis by inducing MDM2 degradation in small-cell lung cancer. Kaohsiung J Med Sci. 2019 Apr;35 (4) :202-208. |[3]A Sobke, et al. The urinary antibiotic 5-nitro-8-hydroxyquinoline (Nitroxoline) reduces the formation and induces the dispersal of Pseudomonas aeruginosa biofilms by chelation of iron and zinc. Antimicrob Agents Chemother. 2012 Nov;56 (11) :6021-5.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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