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Nitroxoline

CAT: 0804-HY-B1159-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B1159-01Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Nitroxoline (8-Hydroxy-5-nitroquinoline), an antibiotic, is an orally active antibiofilm agent. Nitroxoline reduces the formation and induces the dispersal of Pseudomonas aeruginosa biofilms by chelation of iron and zinc. Nitroxoline can be used for the urinary tract infections and cancer research[1][2][3].
CAS Number
4008-48-4
Product Name Alternative
8-Hydroxy-5-nitroquinoline; 5-Nitro-8-quinolinol
UNSPSC
12352005
Hazard Statement
H301+H311+H331, H315, H319, H335
Target
Antibiotic; Apoptosis; Autophagy; Bacterial
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis; Autophagy
Applications
COVID-19-immunoregulation
Field of Research
Infection; Cancer
Assay Protocol
https://www.medchemexpress.com/Nitroxoline.html
Concentration
10mM
Purity
99.90
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
OC1=C2N=CC=CC2=C([N+]([O-])=O)C=C1
Molecular Formula
C9H6N2O3
Molecular Weight
190.16
Precautions
H301+H311+H331, H315, H319, H335
References & Citations
[1]Jin-Guo Yu, et al. Nitroxoline induces cell apoptosis by inducing MDM2 degradation in small-cell lung cancer. Kaohsiung J Med Sci. 2019 Apr;35 (4) :202-208. |[2]A Sobke, et al. The urinary antibiotic 5-nitro-8-hydroxyquinoline (Nitroxoline) reduces the formation and induces the dispersal of Pseudomonas aeruginosa biofilms by chelation of iron and zinc. Antimicrob Agents Chemother. 2012 Nov;56 (11) :6021-5.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

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