Ibudilast-d3

• Description:

  Ibudilast-d3 (KC-404-d3) is the deuterium labeled Ibudilast. Ibudilast (KC-404) is a cyclic AMP phosphodiesterase (PDE) inhibitor. Ibudilast has platelet anti-aggregatory effects. Ibudilast can be used for the research of asthma for its inhibitory effects on tracheal smooth muscle contractility. Ibudilast may be a useful neuroprotective and anti-dementia agent counteracting neurotoxicity in activated microglia[1][2].

• UNSPSC:

  12352005

• Target:

  Isotope-Labeled Compounds; Phosphodiesterase (PDE)

• Related Pathways:

  Metabolic Enzyme/Protease; Others

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology; Cancer

• Solubility:

  10 mM in DMSO

• Smiles:

  C(C(C)C)(=O)C1=C2N(N=C1C(C)C)C(=C(C(=C2[2H])[2H])[2H])[2H]

• Molecular Formula:

  C14H14D4N2O

• Molecular Weight:

  233.32

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Mizuno T, et al. Neuroprotective role of phosphodiesterase inhibitor ibudilast on neuronal cell death induced by activated microglia. Neuropharmacology. 2004 Mar;46 (3) :404-11.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported

• CAS Number:

  [102064-45-9]