Ibudilast

CAT: 0804-HY-B0763-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B0763-01Size:5 mg
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Description
Ibudilast (KC-404; AV-411; MN-166) is a cyclic AMP phosphodiesterase (PDE) inhibitor. Ibudilast has platelet anti-aggregatory effects. Ibudilast can be used for the research of asthma for its inhibitory effects on tracheal smooth muscle contractility. Ibudilast may be a useful neuroprotective and anti-dementia agent counteracting neurotoxicity in activated microglia[1].
CAS Number
[50847-11-5]
Product Name Alternative
KC-404; AV-411; MN-166
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cancer
Assay Protocol
https://www.medchemexpress.com/Ibudilast.html
Concentration
10mM
Purity
99.87
Solubility
DMSO : ≥ 140 mg/mL|H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CC(C)C(C1=C2C=CC=CN2N=C1C(C)C)=O
Molecular Formula
C14H18N2O
Molecular Weight
230.31
Precautions
H302, H315, H319, H335
References & Citations
[1]Mizuno T, et al. Neuroprotective role of phosphodiesterase inhibitor ibudilast on neuronal cell death induced by activated microglia. Neuropharmacology. 2004 Mar;46 (3) :404-11.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

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