Ibudilast

• Description:

  Ibudilast (KC-404; AV-411; MN-166) is a cyclic AMP phosphodiesterase (PDE) inhibitor. Ibudilast has platelet anti-aggregatory effects. Ibudilast can be used for the research of asthma for its inhibitory effects on tracheal smooth muscle contractility. Ibudilast may be a useful neuroprotective and anti-dementia agent counteracting neurotoxicity in activated microglia[1].

• Product Name Alternative:

  KC-404; AV-411; MN-166

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Phosphodiesterase (PDE)

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Ibudilast.html

• Concentration:

  10mM

• Purity:

  99.87

• Solubility:

  DMSO : ≥ 140 mg/mL|H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  CC(C)C(C1=C2C=CC=CN2N=C1C(C)C)=O

• Molecular Formula:

  C14H18N2O

• Molecular Weight:

  230.31

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Mizuno T, et al. Neuroprotective role of phosphodiesterase inhibitor ibudilast on neuronal cell death induced by activated microglia. Neuropharmacology. 2004 Mar;46 (3) :404-11.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• CAS Number:

  50847-11-5