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Quinapril-d4

CAT: 0804-HY-B0477AS2Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-B0477AS2Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Quinapril-d4 (CI-906-d4) is deuterium labeled Quinapril. Quinapril is a potent, orally active, non-peptide and nonsulfhydryl inhibitor of angiotensin-converting enzyme (ACE) . Quinapril specifically interrupts the conversion of angiotensin I to angiotensin II in both plasma and tissue. Quinapril is enzymatically hydrolyzed to a pharmacologically active diacid form quinaprilat. Quinapril is efficacious in hypertensive models[1].
Product Name Alternative
CI-906-d4
UNSPSC
12352005
Target
Angiotensin-converting Enzyme (ACE) ; Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease; Others
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Smiles
CCOC([C@H](CCC1=CC=CC=C1)N[C@@H](C)C(N2[C@@H](CC3=C([2H])C([2H])=C([2H])C([2H])=C3C2)C(O)=O)=O)=O
Molecular Formula
C25H26D4N2O5
Molecular Weight
442.54
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Kaplan HR, et, al. Quinapril--a preclinical review of the pharmacology, pharmacokinetics, and toxicology. Angiology. 1989 Apr;40 (4 Pt 2) :335-50.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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