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Eplerenone-d3

CAT: 0804-HY-B0251SSize: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0251SSize:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Eplerenone-d3 is the deuterium labeled Eplerenone. Eplerenone (Epoxymexrenone) is a selective, competitive and oreally active aldosterone antagonist with an IC50 of 138 nM. Eplerenone has low affinity for progesterone, androgen, estrogen and glucocorticoid receptors. Eplerenone can be used for hypertension and heart failure after myocardial infarction reserch[1][2].
Product Name Alternative
Epoxymexrenone-d3
UNSPSC
12352005
Target
Endogenous Metabolite; Isotope-Labeled Compounds; Mineralocorticoid Receptor
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease; Others; Vitamin D Related/Nuclear Receptor
Field of Research
Cardiovascular Disease
Solubility
10 mM in DMSO
Smiles
O=C(CC1)O[C@@]21CC[C@@]3([H])[C@]4([H])[C@H](C(OC([2H])([2H])[2H])=O)CC5=CC(CC[C@]5(C)[C@@]46[C@H](O6)C[C@@]32C)=O
Molecular Formula
C24H27D3O6
Molecular Weight
417.51
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Dhillon, S., Eplerenone: a review of its use in patients with chronic systolic heart failure and mild symptoms. Drugs, 2013. 73 (13) : p. 1451-62.|[3]Marvin J Meyers, et al. Discovery of (3S,3aR) -2- (3-chloro-4-cyanophenyl) -3-cyclopentyl-3,3a,4,5-tetrahydro-2H-benzo[g]indazole-7-carboxylic acid (PF-3882845), an orally efficacious mineralocorticoid receptor (MR) antagonist for hypertension and nephropathy. J Med Chem. 2010 Aug 26;53 (16) :5979-6002.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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