Sumatriptan-d6

• Description :

  Sumatriptan-d6 is the deuterium labeled Sumatriptan. Sumatriptan is an orally active 5-HT1 receptor agonist with Kis of 17 nM, 27 nM and 100 nM for 5-HT1D, 5-HT1B and 5-HT1A receptors, respectively. Sumatriptan can be used for migraine headache research[1][2][3].

• Product Name Alternative :

  GR 43175 free base-d6

• UNSPSC :

  12352005

• Target :

  5-HT Receptor; Isotope-Labeled Compounds

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling; Others

• Field of Research :

  Neurological Disease

• Solubility :

  10 mM in DMSO

• Smiles :

  O=S(CC1=CC2=C(NC=C2CCN(C([2H])([2H])[2H])C([2H])([2H])[2H])C=C1)(NC)=O

• Molecular Formula :

  C14H15D6N3O2S

• Molecular Weight :

  301.44

• References & Citations :

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]S J Peroutka, et al. Sumatriptan (GR 43175) interacts selectively with 5-HT1B and 5-HT1D binding sites. Eur J Pharmacol. 1989 Apr 12;163 (1) :133-6. |[3]K L Dechant, et al. Sumatriptan. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in the acute treatment of migraine and cluster headache. Drugs. 1992 May;43 (5) :776-98.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported

• CAS Number :

  [1020764-38-8]