Sumatriptan

• Description :

  Sumatriptan (GR 43175) is an orally active 5-HT1 receptor agonist with IC50s of 7.3 nm, 9.3nm and 17.8 nm for 5-HT1D, 5-HT1B and 5-HT1F receptors, respectively. Sumatriptan can be used for migraine headache research[1][2][3][4].

• Product Name Alternative :

  GR 43175 free base

• UNSPSC :

  12352005

• Hazard Statement :

  H361, H412

• Target :

  5-HT Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/sumatriptan.html

• Purity :

  99.96

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  O=S(CC1=CC2=C(NC=C2CCN(C)C)C=C1)(NC)=O

• Molecular Formula :

  C14H21N3O2S

• Molecular Weight :

  295.41

• Precautions :

  H361, H412

• References & Citations :

  [1]K L Dechant, et al. Sumatriptan. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in the acute treatment of migraine and cluster headache. Drugs. 1992 May;43 (5) :776-98.|[2]S J Peroutka, et al. Sumatriptan (GR 43175) interacts selectively with 5-HT1B and 5-HT1D binding sites. Eur J Pharmacol. 1989 Apr 12;163 (1) :133-6. |[3]Razzaque Z, et al. Vasoconstriction in human isolated middle meningeal arteries: determining the contribution of 5-HT1B- and 5-HT1F-receptor activation. Br J Clin Pharmacol. 1999 Jan;47 (1) :75-82.|[4]Bates EA, et al. Sumatriptan alleviates nitroglycerin-induced mechanical and thermal allodynia in mice. Cephalalgia. 2010 Feb;30 (2) :170-8.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• Isoform :

  5-HT1 Receptor; mLAG-3

• Citation 01 :

  ACS Environ Au. 2025 Aug 8.|Anal Chem. 2025 Jun 3;97 (21) :11099-11109.|Cell Rep Methods. 2023 Oct 23;3 (10) :100599.|J Headache Pain. 2024 Oct 30;25 (1) :187.|Mol Pharmacol. 2023 Nov;104 (5) :230-238.|Personalized Medicine Universe. 2019 May.

• CAS Number :

  [103628-46-2]