Sumatriptan

CAT: 0804-HY-B0121B-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B0121B-01Size:25 mg
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Description
Sumatriptan (GR 43175) is an orally active 5-HT1 receptor agonist with IC50s of 7.3 nm, 9.3nm and 17.8 nm for 5-HT1D, 5-HT1B and 5-HT1F receptors, respectively. Sumatriptan can be used for migraine headache research[1][2][3][4].
CAS Number
[103628-46-2]
Product Name Alternative
GR 43175 free base
UNSPSC
12352005
Hazard Statement
H361, H412
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/sumatriptan.html
Purity
99.96
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=S(CC1=CC2=C(NC=C2CCN(C)C)C=C1)(NC)=O
Molecular Formula
C14H21N3O2S
Molecular Weight
295.41
Precautions
H361, H412
References & Citations
[1]K L Dechant, et al. Sumatriptan. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in the acute treatment of migraine and cluster headache. Drugs. 1992 May;43 (5) :776-98.|[2]S J Peroutka, et al. Sumatriptan (GR 43175) interacts selectively with 5-HT1B and 5-HT1D binding sites. Eur J Pharmacol. 1989 Apr 12;163 (1) :133-6. |[3]Razzaque Z, et al. Vasoconstriction in human isolated middle meningeal arteries: determining the contribution of 5-HT1B- and 5-HT1F-receptor activation. Br J Clin Pharmacol. 1999 Jan;47 (1) :75-82.|[4]Bates EA, et al. Sumatriptan alleviates nitroglycerin-induced mechanical and thermal allodynia in mice. Cephalalgia. 2010 Feb;30 (2) :170-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
5-HT1 Receptor; mLAG-3
Citation 01
ACS Environ Au. 2025 Aug 8.|Anal Chem. 2025 Jun 3;97 (21) :11099-11109.|Cell Rep Methods. 2023 Oct 23;3 (10) :100599.|J Headache Pain. 2024 Oct 30;25 (1) :187.|Mol Pharmacol. 2023 Nov;104 (5) :230-238.|Personalized Medicine Universe. 2019 May.

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