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(R) -Doxazosin

CAT: 0804-HY-B0098BSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-B0098BSize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(R) -Doxazosin ((R) -UK 33274) is an isomer of Doxazosin, a selective and orally active a1-adrenoceptor agonist. Doxazosin can be used for systemic antihypertensive and ocular hypotensive. Doxazosin exerts its antihypertensive effect by reducing total peripheral resistance by selective postsynaptic a1-blockade, without reducing cardiac output. Doxazosin can significantly lower both standing and supine blood pressure[1].
CAS Number
70918-17-1
Product Name Alternative
(R) -UK 33274
UNSPSC
12352005
Hazard Statement
H315-H319-H320
Target
Adrenergic Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Metabolic Disease
Smiles
O=C(N1CCN(C2=NC(N)=C3C=C(OC)C(OC)=CC3=N2)CC1)[C@@H]4OC5=CC=CC=C5OC4
Molecular Formula
C23H25N5O5
Molecular Weight
451.48
Precautions
P264-P280-P302+P352-P305+P351+P338-P362
References & Citations
[1]Young, R. A., & Brogden, R. N. (1988) . Doxazosin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in mild or moderate hypertension. Drugs, 35 (5), 525–541.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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