Doxazosin

• Description :

  Doxazosin (UK 33274) is a quinazoline-derivative that selectively antagonizes postsynaptic α1-adrenergic receptors.

• Product Name Alternative :

  UK 33274

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H314, H373, H411

• Target :

  Adrenergic Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Cardiovascular Disease; Endocrinology

• Assay Protocol :

  https://www.medchemexpress.com/doxazosin.html

• Purity :

  99.85

• Solubility :

  DMSO : ≥ 100 mg/mL

• Smiles :

  O=C(N1CCN(C2=NC(N)=C3C=C(OC)C(OC)=CC3=N2)CC1)C4OC5=CC=CC=C5OC4

• Molecular Formula :

  C23H25N5O5

• Molecular Weight :

  451.48

• Precautions :

  H302, H314, H373, H411

• References & Citations :

  [1]Sun, J.A., et al., Stereoselective binding of doxazosin enantiomers to plasma proteins from rats, dogs and humans in vitro. Acta Pharmacol Sin, 2013. 34 (12) : p. 1568-74.|[2]D'Eletto, R.D. and N.B. Javitt, Effect of doxazosin on cholesterol synthesis in cell culture. J Cardiovasc Pharmacol, 1989. 13 Suppl 2: p. S1-4; discussion S4.|[3]Miura, Y. and K. Yoshinaga, Doxazosin: a newly developed, selective alpha 1-inhibitor in the management of patients with pheochromocytoma. Am Heart J, 1988. 116 (6 Pt 2) : p. 1785-9.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light, stored under nitrogen)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• Isoform :

  α adrenergic receptor

• Citation 01 :

  PLoS Negl Trop Dis. 2019 Aug 20;13 (8) :e0007681. |Drug Deliv Transl Res. 2025 Apr 22.

• CAS Number :

  [74191-85-8]