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Doxazosin

CAT: 0804-HY-B0098-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0098-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Doxazosin (UK 33274) is a quinazoline-derivative that selectively antagonizes postsynaptic α1-adrenergic receptors.
CAS Number
74191-85-8
Product Name Alternative
UK 33274
UNSPSC
12352005
Hazard Statement
H302, H314, H373, H411
Target
Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cardiovascular Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/doxazosin.html
Purity
99.85
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(N1CCN(C2=NC(N)=C3C=C(OC)C(OC)=CC3=N2)CC1)C4OC5=CC=CC=C5OC4
Molecular Formula
C23H25N5O5
Molecular Weight
451.48
Precautions
H302, H314, H373, H411
References & Citations
[1]Sun, J.A., et al., Stereoselective binding of doxazosin enantiomers to plasma proteins from rats, dogs and humans in vitro. Acta Pharmacol Sin, 2013. 34 (12) : p. 1568-74.|[2]D'Eletto, R.D. and N.B. Javitt, Effect of doxazosin on cholesterol synthesis in cell culture. J Cardiovasc Pharmacol, 1989. 13 Suppl 2: p. S1-4; discussion S4.|[3]Miura, Y. and K. Yoshinaga, Doxazosin: a newly developed, selective alpha 1-inhibitor in the management of patients with pheochromocytoma. Am Heart J, 1988. 116 (6 Pt 2) : p. 1785-9.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
α adrenergic receptor
Citation 01
PLoS Negl Trop Dis. 2019 Aug 20;13 (8) :e0007681. |Drug Deliv Transl Res. 2025 Apr 22.

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